Dr. Lonny R. Levin is a Professor of Pharmacology at Weill Cornell Medicine, New York, NY, USA.

In 1999 in collaboration with Dr. Jochen Buck, he purified and cloned mammalian soluble adenylyl cyclase (sAC, ADCY10). Together they demonstrated that sAC activity is directly regulated by bicarbonate ions and functions as a biological sensor for carbon dioxide, bicarbonate, and pH. By 2000, Drs. Levin and Buck merged their research programs into a single program studying sAC biology. Their combined laboratory developed the most widely used genetic, pharmacologic, and immunologic reagents for studying sAC. In 2005, they demonstrated genetically and pharmacologically that sAC in sperm is essential for male fertility, and in 2014, in collaboration with Dr. Clemens Steegborn, they structurally and biochemically elucidated its mechanism of bicarbonate regulation. Most recently, in concert with Dr. Steegborn and Dr. Peter T. Meinke and his team at TDI, Drs. Levin and Buck designed, developed, and leveraged potent and drug-like sAC inhibitors to establish the revolutionary paradigm of on-demand contraception in males.

For his PhD at Cold Spring Harbor Laboratory, Dr. Levin studied the cAMP signaling pathway and regulation of Protein Kinase A (PKA). During his post-doctoral training, as a Howard Hughes Fellow at Johns Hopkins School of Medicine, he cloned and characterized the Rutabaga adenylyl cyclase integral for learning and memory formation in Drosophila melanogaster. He started as a faculty member at Weill Cornell Medicine in 1994, where he soon began his long-term collaboration with Dr. Jochen Buck.